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Function Health biomarker list

The complete list of 128 biomarkers Function tests, grouped by category with notes on what each panel actually tells you.

Function Health markets the panel as "100+ biomarkers." The exact count fluctuates as Function adds and tweaks tests, but the panel you actually receive includes around 128 distinct markers across roughly 18 categories. The list below is based on Function's published panel; check their official page for the most up-to-date version.

A few things to note about how Function structures the panel: the annual draw includes the full 128-marker set, and the mid-year follow-up draw covers about 60 of the most action-relevant markers (mostly heart, metabolic, thyroid, and inflammation). Hormones and one-time-genetic markers like Lp(a) usually aren't repeated mid-year. The "100+" framing also counts urinalysis fields (color, appearance, pH, etc.) as individual biomarkers, which inflates the headline number a bit.

Heart & Lipids (15 markers)

Function's heart panel goes well beyond the basic lipid profile. Alongside total cholesterol, LDL, HDL, and triglycerides, you get advanced markers like ApoB (the actual count of atherogenic particles), Lipoprotein(a) — a largely genetic risk factor most doctors never order — and an NMR breakdown of LDL particle size and number. The combination is closer to what a preventive cardiologist would order than a standard physical.

  • Apolipoprotein B
  • Lipoprotein (a)
  • HDL Cholesterol
  • Large HDL Particles
  • LDL Particle Number
  • LDL Pattern
  • LDL Peak Size
  • High-Sensitivity C-Reactive Protein
  • Medium LDL Particles
  • Small LDL Particles
  • Non-HDL Cholesterol
  • Triglycerides
  • Cholesterol/HDL Ratio
  • LDL Cholesterol
  • Total Cholesterol

Metabolic (4 markers)

Glucose, Hemoglobin A1c, leptin, and uric acid. Notably absent: fasting insulin, which would let you calculate HOMA-IR for early insulin resistance. Leptin is an interesting inclusion — it tracks adiposity and can signal leptin resistance in people carrying excess weight.

  • Glucose
  • Hemoglobin A1c
  • Leptin
  • Uric Acid

Thyroid (5 markers)

TSH alone is the standard screen, but Function adds Free T3, Free T4, and thyroglobulin antibodies, which is what you'd want to actually understand thyroid function rather than just rule out gross hypothyroidism. Selenium gets included here because it's a cofactor for the deiodinase enzymes that convert T4 to T3.

  • Thyroglobulin Antibodies
  • Thyroid-Stimulating Hormone
  • Free T3 (Triiodothyronine)
  • Free T4 (Thyroxine)
  • Selenium

Female hormones (9 markers)

AMH (a marker of ovarian reserve), FSH, LH, prolactin, estradiol, SHBG, total and free testosterone, and DHEA-S. AMH is the standout here — it's the closest thing to a fertility timeline marker and one of the few hormone tests where Function's panel matches what a reproductive endocrinologist would order.

  • Anti-Mullerian Hormone (AMH)
  • Sex Hormone Binding Globulin (SHBG)
  • Follicle Stimulating Hormone (FSH)
  • Prolactin
  • DHEA-Sulfate
  • Testosterone Free
  • Testosterone Total
  • Luteinizing Hormone (LH)
  • Estradiol (E2)

Male-specific (4 markers)

DHEA-Sulfate, FSH, and free + total PSA. The male hormone story is mostly carried by markers shared with the female panel (testosterone, SHBG, estradiol), which Function tests for everyone.

  • DHEA-Sulfate
  • Follicle Stimulating Hormone (FSH)
  • PSA Free
  • PSA Total

Stress and aging (2 markers)

Cortisol and DHEA-Sulfate. A morning blood cortisol is a snapshot, not the diurnal curve you'd get from saliva or urine, but combined with DHEA-S it gives a rough read on adrenal output.

  • Cortisol
  • DHEA-Sulfate

Vitamins, minerals, and nutrients (19 markers)

Function tests vitamin D, the full iron panel (iron, ferritin, saturation, TIBC), magnesium, zinc, homocysteine, and methylmalonic acid (a more sensitive B12 status marker). The omega panel is unusually detailed — total omega-3, EPA, DHA, DPA, the omega-6/omega-3 ratio, and arachidonic acid/EPA ratio. That's closer to an OmegaQuant test than what most labs offer.

  • Arachidonic Acid/EPA Ratio
  • Calcium
  • Ferritin
  • Homocysteine
  • Iron
  • Iron Saturation
  • Total Iron Binding Capacity
  • Magnesium
  • Methylmalonic Acid
  • Omega-3 Total
  • Omega-3 DHA
  • Omega-3 DPA
  • Omega-3 EPA
  • Omega-6/Omega-3 Ratio
  • Omega-6 Total
  • Omega-6 Arachidonic Acid
  • Omega-6 Linoleic Acid
  • Vitamin D
  • Zinc

Liver (8 markers)

ALT, AST, ALP, GGT, total bilirubin, albumin, globulin, and the albumin/globulin ratio. GGT is the more sensitive marker for alcohol-related stress on the liver and bile flow issues. Together these cover the standard liver function panel.

  • Alanine Aminotransferase
  • Albumin
  • Albumin/Globulin Ratio
  • Alkaline Phosphatase
  • Aspartate Aminotransferase
  • Gamma-Glutamyl Transferase
  • Globulin
  • Bilirubin

Kidney (9 markers)

Creatinine, BUN, BUN/creatinine ratio, eGFR, and the major electrolytes (sodium, potassium, calcium, chloride). eGFR is the headline metric for kidney function and gets calculated from creatinine.

  • Albumin
  • BUN (Blood Urea Nitrogen)
  • BUN/Creatinine Ratio
  • Calcium
  • Chloride
  • Creatinine
  • eGFR (Estimated Glomerular Filtration Rate)
  • Potassium
  • Sodium

Pancreas (2 markers)

Amylase and lipase. These are mostly useful for ruling out pancreatitis or chronic pancreatic stress; they're not particularly informative for healthy people but cheap to include in the panel.

  • Amylase
  • Lipase

Complete blood count (8 markers)

ABO blood group, RBC count, hemoglobin, hematocrit, MCV, MPV, platelet count, and RDW. RDW (red cell distribution width) has gotten attention as an all-cause mortality marker in observational studies — elevated RDW often shows up before more obvious problems.

  • ABO Blood Group
  • Hematocrit
  • Hemoglobin
  • Mean Corpuscular Volume (MCV)
  • Mean Platelet Volume (MPV)
  • Platelets
  • Red Blood Cell Count
  • Red Cell Distribution Width (RDW)

Electrolytes (6 markers)

Sodium, potassium, calcium, magnesium, chloride, and CO2. There's overlap with the kidney panel — Function reports these in both contexts because they tell different stories depending on what else is happening.

  • Calcium
  • Carbon Dioxide (CO2)
  • Chloride
  • Magnesium
  • Potassium
  • Sodium

Immune regulation (7 markers)

hsCRP for systemic inflammation plus a full white blood cell differential — neutrophils, lymphocytes, monocytes, eosinophils, basophils, and total WBC. The differential can hint at infection patterns, allergic activity (eosinophils), or chronic inflammation.

  • High-Sensitivity C-Reactive Protein
  • Basophils
  • Lymphocytes
  • Neutrophils
  • Eosinophils
  • Monocytes
  • White Blood Cell Count

Autoimmune (4 markers)

Anti-Nuclear Antibodies (ANA) screen, titer, and pattern, plus Rheumatoid Factor. ANA is a broad screen that can flag lupus, Sjögren's, and several other autoimmune conditions; positive results need follow-up because the test has a meaningful false positive rate.

  • Anti-Nuclear Antibodies Pattern
  • Anti-Nuclear Antibodies Titer
  • Anti-Nuclear Antibodies Screen
  • Rheumatoid Factor

Cancer markers (PSA) (3 markers)

Total PSA, Free PSA, and Percent Free PSA. The percent-free ratio is more informative than total PSA alone for distinguishing benign prostatic hyperplasia from cancer. Note that Function's main panel doesn't include the Galleri multi-cancer test — that's a separate add-on.

  • PSA Percent Free
  • PSA Free
  • PSA Total

Urinalysis (20 markers)

Function runs a full urinalysis: appearance, color, pH, specific gravity, protein, glucose, ketones, blood, nitrite, leukocyte esterase, and microscopic findings (casts, crystals, epithelial cells, RBCs, WBCs, bacteria, yeast). It's a dense test that can flag kidney issues, UTIs, dehydration, and metabolic problems for very little marginal cost.

  • Albumin
  • Amorphous Sediment
  • Urine Appearance
  • Urine Bacteria
  • Urine Bilirubin
  • Calcium Oxalate Crystals
  • Urine Color
  • Urine Glucose
  • Hyaline Casts
  • Ketones
  • Urine Leukocyte Esterase
  • Urine Nitrite
  • Urine Blood
  • Urine pH
  • Urine Protein
  • Urine Red Blood Cells
  • Urine Specific Gravity
  • Squamous Epithelial Cells
  • Urine White Blood Cells
  • Urine Yeast

Heavy metals (2 markers)

Lead and mercury. Mercury is the more common positive in adults — usually traceable to seafood consumption — while lead exposure is rarer in modern adults but worth checking once.

  • Lead
  • Mercury

Composite scores (1 markers)

Biological age — a composite estimate from the panel. Function's biological age tends to skew optimistic (most users get a number lower than their chronological age), which is fun but not particularly diagnostic.

  • Biological Age

How Function's biomarker list compares

Compared to a standard annual physical (which usually orders a CBC, CMP, lipid panel, TSH, and maybe vitamin D — call it 25-30 markers), Function's panel is roughly 3-4x broader. The biggest gains are in the heart panel (ApoB, Lp(a), LDL particle analysis), the omega-3 panel, and the hormone coverage.

Compared to direct competitors: Superpower covers most of the same ground at $199 but skips the advanced LDL subfraction analysis and the omega panel. InsideTracker's Ultimate panel is comparable in breadth but pricier. Marek Health leans heavier on hormones and lighter on urinalysis and nutrients.

For a side-by-side breakdown, see Function vs Superpower.