Function Health: breakdown, review, and alternatives
Function Health, founded by Mark Hyman, offers 100+ biomarkers for $499 per year, with re-testing of 60 of the biomarkers mid-year. Dr Hyman started the Cleveland Clinic's Functional Medicine program and was made famous by The Katie Couric Show.
I tried Function Health when they first launched. The appeal of getting a bunch of really advanced biomarkers (ApoB, Lp(a), particle sizes, hormones, etc) without doctor gatekeeping was obvious. I also liked the idea of getting the Grail multi-cancer test.
Here's what I think Function did well: the blood test report is attractive and well-designed, with nice colors.
Where I think Function could improve is the follow up. The "clinician report" that you get is essentially written by ChatGPT, it recommends some supplements, but aside from that, there's not much. The mobile apps just let you view your results. You can't track results over time since there's no way to upload PDFs of previous blood tests.
I think Function's price of $365 is also higher than newer alternatives, like Superpower ($199) and Empirical ($190).
Overall, I think Function Health is a good option for those who want a comprehensive blood test, but I think they'll need to step up their game to stay competitive.
What's included in Function's blood test
| Feature / Biomarker | Annual Membership |
|---|---|
| Price | $499 |
| Number of Biomarkers | 128 |
| Features | |
| Mobile App | ✓ |
| Web App | ✓ |
| Doctor Review | |
| Testing Frequency | Twice per year (Annual: 100+ tests, Follow-up: 60+ tests) |
| Nutrition Plans | |
| Prescriptions (if necessary) | |
| Biomarkers | |
| ABO Blood Group | ✓ |
| Alanine Aminotransferase | ✓ |
| Albumin | ✓ |
| Albumin/Globulin Ratio | ✓ |
| Alkaline Phosphatase | ✓ |
| Amorphous Sediment | ✓ |
| Amylase | ✓ |
| Anti-Mullerian Hormone (AMH) | ✓ |
| Anti-Nuclear Antibodies Pattern | ✓ |
| Anti-Nuclear Antibodies Screen | ✓ |
| Anti-Nuclear Antibodies Titer | ✓ |
| Apolipoprotein B | ✓ |
| Arachidonic Acid/EPA Ratio | ✓ |
| Aspartate Aminotransferase | ✓ |
| BUN (Blood Urea Nitrogen) | ✓ |
| BUN/Creatinine Ratio | ✓ |
| Basophils | ✓ |
| Bilirubin | ✓ |
| Biological Age | ✓ |
| Calcium | ✓ |
| Calcium Oxalate Crystals | ✓ |
| Carbon Dioxide (CO2) | ✓ |
| Chloride | ✓ |
| Cholesterol/HDL Ratio | ✓ |
| Cortisol | ✓ |
| Creatinine | ✓ |
| DHEA-Sulfate | ✓ |
| Eosinophils | ✓ |
| Estradiol (E2) | ✓ |
| Ferritin | ✓ |
| Follicle Stimulating Hormone (FSH) | ✓ |
| Free T3 (Triiodothyronine) | ✓ |
| Free T4 (Thyroxine) | ✓ |
| Gamma-Glutamyl Transferase | ✓ |
| Globulin | ✓ |
| Glucose | ✓ |
| HDL Cholesterol | ✓ |
| Hematocrit | ✓ |
| Hemoglobin | ✓ |
| Hemoglobin A1c | ✓ |
| High-Sensitivity C-Reactive Protein | ✓ |
| Homocysteine | ✓ |
| Hyaline Casts | ✓ |
| Iron | ✓ |
| Iron Saturation | ✓ |
| Ketones | ✓ |
| LDL Cholesterol | ✓ |
| LDL Particle Number | ✓ |
| LDL Pattern | ✓ |
| LDL Peak Size | ✓ |
| Large HDL Particles | ✓ |
| Lead | ✓ |
| Leptin | ✓ |
| Lipase | ✓ |
| Lipoprotein (a) | ✓ |
| Luteinizing Hormone (LH) | ✓ |
| Lymphocytes | ✓ |
| Magnesium | ✓ |
| Mean Corpuscular Volume (MCV) | ✓ |
| Mean Platelet Volume (MPV) | ✓ |
| Medium LDL Particles | ✓ |
| Mercury | ✓ |
| Methylmalonic Acid | ✓ |
| Monocytes | ✓ |
| Neutrophils | ✓ |
| Non-HDL Cholesterol | ✓ |
| Omega-3 DHA | ✓ |
| Omega-3 DPA | ✓ |
| Omega-3 EPA | ✓ |
| Omega-3 Total | ✓ |
| Omega-6 Arachidonic Acid | ✓ |
| Omega-6 Linoleic Acid | ✓ |
| Omega-6 Total | ✓ |
| Omega-6/Omega-3 Ratio | ✓ |
| PSA Free | ✓ |
| PSA Percent Free | ✓ |
| PSA Total | ✓ |
| Platelets | ✓ |
| Potassium | ✓ |
| Prolactin | ✓ |
| Red Blood Cell Count | ✓ |
| Red Cell Distribution Width (RDW) | ✓ |
| Rheumatoid Factor | ✓ |
| Selenium | ✓ |
| Sex Hormone Binding Globulin (SHBG) | ✓ |
| Small LDL Particles | ✓ |
| Sodium | ✓ |
| Squamous Epithelial Cells | ✓ |
| Testosterone Free | ✓ |
| Testosterone Total | ✓ |
| Thyroglobulin Antibodies | ✓ |
| Thyroid-Stimulating Hormone | ✓ |
| Total Cholesterol | ✓ |
| Total Iron Binding Capacity | ✓ |
| Triglycerides | ✓ |
| Uric Acid | ✓ |
| Urine Appearance | ✓ |
| Urine Bacteria | ✓ |
| Urine Bilirubin | ✓ |
| Urine Blood | ✓ |
| Urine Color | ✓ |
| Urine Glucose | ✓ |
| Urine Leukocyte Esterase | ✓ |
| Urine Nitrite | ✓ |
| Urine Protein | ✓ |
| Urine Red Blood Cells | ✓ |
| Urine Specific Gravity | ✓ |
| Urine White Blood Cells | ✓ |
| Urine Yeast | ✓ |
| Urine pH | ✓ |
| Vitamin D | ✓ |
| White Blood Cell Count | ✓ |
| Zinc | ✓ |
| eGFR (Estimated Glomerular Filtration Rate) | ✓ |
Note: the above table is accurate as of Dec 2025, when I wrote this. But check their latest page since they may change their biomarkers from time to time.
Function platform features
Function does twice-per-year testing
Function Health provides two comprehensive lab visits per year. The first annual test includes 100+ biomarkers, followed by a mid-year test with 60+ biomarkers to track changes and progress.
Function's Mobile & Web Apps
Function Health offers both a web dashboard, iPhone app, and Android apps where you can view your results, track trends over time, and access your health data. The interface is designed to make complex biomarker data accessible, and honestly just looks a lot better than the built-in Quest report.
No insurance
Function Health operates outside the insurance system. On the bright side, this means the pricing is transparent. On the other hand, some of the biomarkersare covered by insurance, so I have to feel like there's a cheaper version of this.